Autophagy in Load-Induced Heart Disease
نویسندگان
چکیده
منابع مشابه
Crosstalk Between Autophagy and Apoptosis in Heart Disease Autophagy in Ischemic Heart Disease Cardiomyocyte Autophagy in Load-Induced Heart Disease Autophagy and Atherosclerosis Molecular Mechanisms of Autophagy
Autophagy is a cell survival mechanism that involves degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. In addition, autophagy mediates cell death under specific circumstances. Apoptosis, a form of programmed cell death, has been well characterized, and the molecular events involved in apoptotic death are well understood. Damaged cardiomyocytes that...
متن کاملCrosstalk Between Autophagy and Apoptosis in Heart Disease [2008;103:343–351] Autophagy in Load-Induced Heart Disease Autophagy in Ischemic Heart Disease Autophagy in Atherosclerosis: A Cell Survival and Death Phenomenon with Therapeutic Potential
The heart is a highly plastic organ capable of remodeling in response to changes in physiological or pathological demand. For example, when workload increases, compensatory hypertrophic growth of individual cardiomyocytes occurs to increase cardiac output. Sustained stress, however, such as that occurring with hypertension or following myocardial infarction, triggers changes in energy metabolis...
متن کاملCrosstalk Between Autophagy and Apoptosis in Heart Disease [2008;103:343–351] Autophagy in Load-Induced Heart Disease [2008;103:1363–1369] Autophagy in Ischemic Heart Disease [2008;104:000-000] Autophagy in Atherosclerosis: A Cell Survival and Death Phenomenon With Therapeutic Potential
Autophagy is a reparative, life-sustaining process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded on fusion with lysosomal compartments. A growing body of evidence suggests that autophagy is stimulated in advanced atherosclerotic plaques by oxidized lipids, inflammation, and metabolic stress conditions. However, despite the increasing interest in autoph...
متن کاملCrosstalk Between Autophagy and Apoptosis in Heart Disease [2008;103:343–351] Autophagy in Load-Induced Heart Disease [2008;103:1363–1369] Autophagy in Ischemic Heart Disease Autophagy in Atherosclerosis: A Cell Survival and Death Phenomenon With Therapeutic Potential
Autophagy is a major catabolic pathway by which mammalian cells degrade and recycle macromolecules and organelles. It plays a critical role in removing protein aggregates, as well as damaged or excess organelles, to maintain intracellular homeostasis and to keep the cell healthy. In the heart, autophagy occurs at low levels under normal conditions, and defects in this process cause cardiac dysf...
متن کاملAutophagy in hypertensive heart disease.
In response to hypertension, the heart manifests robust hypertrophic growth, which offsets load-induced elevations in wall stress. If sustained, this hypertrophic response is a major risk factor for systolic dysfunction and heart failure. Extensive research efforts have focused on the progression from hypertrophy to failure; however, precise understanding of underlying mechanisms remains elusiv...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2008
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.108.186551